Genome-Scale Metabolic Network (IMAGE)
Caption
This image from Boston College researchers depicts the first curated, genome-scale metabolic network of the lethal bacterium Streptococcus pneumoniae; a major cause of illness around the world. Each node represents a metabolite; each branch represents a metabolic gene. Integration of genome-wide data reveals that the phenotypic stress network (red) and the transcriptional stress network (green) consist of distinct gene-sets, undermining the widely held assumption that genes that change in expression upon environmental disturbance must also phenotypically matter.
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Cell Reports
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