The synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at the opposite end of STING where the nature ligand cGAMP (cyan spheres at the top) binds. The synthetic compound and cGAMP together induce much stronger STING activation than either one alone. (IMAGE)

UT Southwestern Medical Center

The synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at the opposite end of STING where the nature ligand cGAMP (cyan spheres at the top) binds. The synthetic compound and cGAMP together induce much stronger STING activation than either one alone.

Caption

The synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at the opposite end of STING where the nature ligand cGAMP (cyan spheres at the top) binds. The synthetic compound and cGAMP together induce much stronger STING activation than either one alone.

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UT Southwestern Medical Center

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