Age-Related Macular Degeneration (IMAGE) University of Pennsylvania School of Medicine Caption Drusen (extracellular deposits of protein and lipids that accumulate and can cause blindness) in macular degeneration. A. Drawing of eye showing location of macula at the center of the retina. B. Photograph of the macula from a patient with drusen. C. Histologic section of retina showing drusen between the retinal pigment epithelium (RPE) and Bruch’s membrane. Credit Eric A. Pierce, MD, PhD; Ann Milam, PhD, University of Pennsylvania School of Medicine; National Eye Institute Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.