Mouse models of Cornelia de Lange syndrome (IMAGE)

Stowers Institute for Medical Research

Mouse models of Cornelia de Lange syndrome

Caption

The placenta is essential for embryo development and acts as an interface between the embryo and mother for the exchange of gas, nutrient, and waste products. Mutations that affect cohesin genes cause the human developmental disorder Cornelia de Lange syndrome (CdLS). Mouse models of CdLS show placental abnormalities such as increased placental size and activated cytokine signaling, which leads to embryo growth retardation.

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Mark M. Miller, Stowers Institute for Medical Research

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