Simultaneous Deletion of Tetraspanins (IMAGE) Osaka University Caption Simultaneous deletion of tetraspanins CD9/CD81 in mice progressively exhibits a variety of accelerating aging phenotypes such as cataracts, osteoporosis, emphysema, skin atrophy, muscle atrophy, and shorter survival. Of note, its underlying mechanism would be downregulation of SIRT1, a key anti-aging molecule. Therefore, DKO mice could be a novel and unique model for both COPD and accelerated senescence. Credit Yoshito Takeda Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.