A Brain Receptor Changes in Response to the Environment (IMAGE)

Cold Spring Harbor Laboratory

A Brain Receptor Changes in Response to the Environment

Caption

Structure of the full NMDA receptor, obtained via cryo-electron microscopy. A structural feature of the GluN1 subunit varies due to alternative RNA splicing enabling the receptor to function when the local environment becomes highly acidic, as during a stroke or epileptic seizure. The change affects the interface in the boxed area, which contains a pH sensor.

Credit

Furukawa Lab, CSHL

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.