Naloxone Structure (IMAGE)

Society for Neuroscience

Naloxone Structure

Caption

Chemical structure of (-)-naloxone and (+)-naloxone enantiomers. Ki of (-)-naloxone for antagonizing opioid receptors is in the 1 nM range whereas (+)-naloxone has a very low affinity for opioid receptors with a Ki of 10 000 nM (Iijima et al., 1978).

Credit

Anttila et al., <i>eNeuro</i> (2018)

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