Diagram Brain Gene Expression Changes (IMAGE) Columbia University Irving Medical Center Caption This diagram shows the overlap of brain gene expression changes in unaffected individuals who carry the APOE4 high-risk variant, unaffected individuals over age 85, and patients with late-onset Alzheimer's disease (LOAD). Credit Courtesy: Dr. Asa Abeliovich, Columbia University's Taub Institute Usage Restrictions With image credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.