Dendritic Branching in Mice (IMAGE)

Columbia University Irving Medical Center

Dendritic Branching in Mice

Caption

The leftmost image -- WT (wildtype), or normal, mice -- shows normal branching of neuronal dendrites. The mice with Alzheimer’s disease (J20) show significant dendritic loss. When caspase-2 was deleted from mice with Alzheimer's (J20/Casp2KO), dendritic branching was normal -- demonstrating that removal of caspase-2 can protect neurons in the presence of amyloid beta.

Credit

Julio Pozueta, Ph.D.

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