The Origin Recognition Complex (IMAGE)

Cold Spring Harbor Laboratory

The Origin Recognition Complex

Caption

The Origin Recognition Complex (ORC) is a group of proteins required to be fully assembled for the first step in DNA replication. One component of the ORC, ORC1 (visible in this image as bright green dots), is sequestered into droplets in the nucleus of the cell, and allowed to move briefly and assemble with other proteins at the right moment in the cell cycle.

Credit

Manzar Hossain/Stillman lab/CSHL, 2021

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