Fluorescence Diffuse Optical Tomography Provides High Contrast, 3-D Look at Breast Cancer (IMAGE)
Caption
a) Illustration the location of the tumor from a patient diagnosed with invasive ductal carcinoma. b) A localized fluorescence uptake is observed from the transillumination image at the lateral side where the tumor is expected to be found. Note that our CCD camera view is caudal-cranial (from foot to head), so the right and left side correspond to lateral and medial sides, respectively, for the right breast. c) Image slices from 3-D tomographic reconstructions display the contrasts of the following physiological parameters: Total hemoglogin concentration (THC), oxygen saturation (StO2), reduced scattering and fluorophore (ICG) concentration. d) From the the profile plot (along the pink line in (c)), we observe that scattering and ICG concentration exhibit up to four- and 5.5-fold contrast, respectively, whereas THC contrast is only 1.3 and and StO2 does not show any significant contrast. The large tumor contrast obtained with a non-targeted exogenous fluorophore (ICG) portends a promising future as molecularly targeted dyes and beacons become available for clinical use. e) 3-D iso-surface images of THC, scattering and ICG concentration contrast. The iso-surfaces of the three contrasts overlay one another quite well.
Credit
Alper Corlu
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