Modification on mRNA (IMAGE) Japan Science and Technology Agency Caption Phosphorothioate modification of mRNA increases the rate of translation initiation and the molecular designs for a high translation efficiency were optimized. This result provides a useful molecular design guideline for improving the translation quantity by chemical modification of mRNA. Credit Nagoya University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.