Autophagy Inhibition (IMAGE)

Luxembourg Institute of Health

Autophagy Inhibition

Caption

By studying melanoma, a highly malignant form of skin cancer, Dr Bassam Janji's research team at the Luxembourg Institute of Health (LIH) has revealed a mechanism by which the immunosuppressive environment can be switched to an immunosupportive one. They found that if autophagy -- the intracellular recycling process -- is blocked in tumor cells, they produce cytokines that attract NK cells. The massive recruitment of NK cells allows killing cancer cells and lets the tumors shrink.

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LIH

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