Circular Non-Coding RNA (IMAGE)
Caption
The genetic variants associated with cardiovascular disease are located within a sequence that produces a long, non‑coding RNA called ANRIL. Individuals at decreased risk for cardiovascular disease are more likely to splice the long RNA into two smaller fragments: a short linear RNA and a novel circular RNA (cANRIL). In contrast, people at increased risk for cardiovascular disease prefer to make the longer ANRIL RNA, which more efficiently silences INK4/ARF gene expression. Expression of the associated INK4/ARF genes protects against the formation of atherosclerotic plaques, and therefore individuals who prefer to silence this locus are more predisposed to cardiovascular disease.
Credit
Used with permission of <i>PLoS Genetics</i>
Usage Restrictions
Image credit as follows: Used with permission of PLOS Genetics
License
Licensed content