Figure 1. thalidomide Inhibits Crbn-Mediated Differentiation of Nscs to Promote Normal Brain Develop (IMAGE)

Tokyo Institute of Technology

Figure 1. thalidomide Inhibits Crbn-Mediated Differentiation of Nscs to Promote Normal Brain Develop

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Normal CRBN activity promotes NSC proliferation and differentiation into neurons and glial cells; however, thalidomide binding to CRBN inhibits this activity, resulting in NSC death, smaller-sized brains, and dysfunctional organ, limb, and/or mental development.

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