Scientists look to tissue chips to study diseases, inform clinical trial design (IMAGE)

NIH/National Center for Advancing Translational Sciences (NCATS)

Scientists look to tissue chips to study diseases, inform clinical trial design

Caption

A tissue model of catecholaminergic polymorphic ventricular tachycardia (CPVT), a leading cause of sudden death from cardiac arrest in children and young adults, on a tissue chip. Scientists from Boston Children's Hospital and Harvard University reprogrammed blood cells from a patient with a gene mutation linked to most cases of CPVT and prompted these cells to become stem cells. These in turn were made into cardiomyocytes (heart muscle cells) carrying CPVT mutations, which were seeded onto an engineered surface. The cells, shown in purple, lined up in a direction similar to how heart muscle is organized and beat together.

Credit

Sung Jin Park/Boston Children's Hospital and Donghui Zhang/Harvard SEAS

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.