Ly6/PLAUR Domain (IMAGE) Osaka University Caption Ly6/PLAUR domain containing 8 (Lypd8), which is a highly glycosylated GPI-anchored protein, is highly and selectively expressed in epithelial cells on the uppermost layer of the intestinal gland and shed into the intestinal lumen. Lypd8 inhibits intestinal bacterial invasion of the colonic mucosa by binding to the intestinal bacteria, and thereby regulates the intestinal inflammation. Credit Osaka University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.