Ly6/PLAUR Domain (IMAGE)

The University of Osaka

Ly6/PLAUR Domain

Caption

Ly6/PLAUR domain containing 8 (Lypd8), which is a highly glycosylated GPI-anchored protein, is highly and selectively expressed in epithelial cells on the uppermost layer of the intestinal gland and shed into the intestinal lumen. Lypd8 inhibits intestinal bacterial invasion of the colonic mucosa by binding to the intestinal bacteria, and thereby regulates the intestinal inflammation.

Credit

Osaka University

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