Fig.1 (IMAGE) Osaka University Caption Loss of function mutations in the cochaperone protein BAG5 can lead to dilated cardiomyopathy and ultimately heart failure through an impaired quality control of junctional membrane complex (JMC) proteins. E-C coupling: Excitation-Contraction coupling Credit © 2022 Hakui H et al., Science Translational Medicine Usage Restrictions None License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.