Simplified Diagram Showing the Role of Pericytes in Stabilizing the Blood-Retinal Barrier (IMAGE)
Caption
(Top) Pericytes (P, green) are cells tightly wrapped around the wall of the retinal capillaries, in close contact with endothelial cells (EC, dark pink) and other supporting cells (blue). These form the blood-retinal barrier and prevent some substances from going from the blood stream to the eye. (Bottom) IBS scientists clarified that the lack of pericytes, a common hallmark of diabetic retinopathy, triggers a vicious cycle that causes an increase in vascular-destabilizing proteins, like Ang2, and a reduction of vascular-stabilizing proteins, like Tie2.
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IBS
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