A New Pathway to Get at HER2-Positive Breast Cancer (IMAGE)

Cold Spring Harbor Laboratory

A New Pathway to Get at HER2-Positive Breast Cancer

Caption

Mammary epithelial cells grow in clusters called acini. When HER2 signaling is activated, the clusters -- which normally have hollow centers -- assume an irregular, or dysplastic form (left). When Tonks and colleagues knocked down expression of the phosphatase PTPD2, the acini returned to their normal shape (right), even when HER2 signaling was activated. Experiments showed that PTPD2 was one element in a previously unknown HER2 signaling pathway, other components of which might be simultaneously targeted in future combination treatments.

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Tonks Lab, CSHL

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