Figure (IMAGE)

Osaka University

Figure

Caption

To induce antibodies predominantly targeting regions in the RBD that are structurally conserved among SARS-related viruses, glycan engineering was performed to mask the non-conserved, dominant epitope on the RBD head region. When mice were immunized with this modified RBD vaccine, antibodies that recognize the core-RBD region of not only SARS-CoV-2 but also other SARS-related viruses, such as SARS-CoV or WIV1-CoV, were predominantly induced. These induced antibodies are highly protective against various SARS-related viruses.

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Ryo Shinnakasu et al.

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