Melatonin inhibits Gram-negative pathogens by targeting citrate synthase (IMAGE)

Science China Press

Melatonin inhibits Gram-negative pathogens by targeting citrate synthase

Caption

Melatonin targets citrate synthase in P. multocida. A: The concentration gradient binding curves of type II citrate synthase with melatonin. B: The binding pocket of predicted citrate synthase with melatonin and small molecule binding site region. C: Interactions between melatonin and the amino acid residues of the binding sites in type II citrate synthase. D-F: The concentration gradient binding curves of melatonin with type II CS (R300A) (D), type II CS (R300A, D363A) (E) and type II CS (R300A, D363A, H265A) (F).

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