Lymph Flow (IMAGE)

University of Pennsylvania School of Medicine

Lymph Flow

Caption

Lymph flow drives development of lymphatic valves in collecting lymphatic vessels in the embryonic mouse mesentery. Two transcription factors: PROX1 (green) and FOXC2 (red) are highly unregulated in the valve endothelial cells, and are required for development of the valves. The extracellular matrix protein Laminin-alpha5 (blue) is expressed in the valve leaflets and in the arterial basement membrane of the underlying artery.

Credit

Daniel Sweet, PhD and Mark Kahn, PhD, Perelman School of Medicine, University of Pennsylvania

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