A Valuable Marker for Prostate Cancer Metastasis (IMAGE)

Cold Spring Harbor Laboratory

A Valuable Marker for Prostate Cancer Metastasis

Caption

In RApidCaP, a mouse model of human metastatic prostate cancer that they developed, Trotman and colleagues have identified an immune system marker that may help to distinguish patients who will and will not respond to hormone therapy. That marker is IL-6, an immune system component whose presence is indicated in brown patches in the image at left, in a section of lung tissue (blue) colonized by prostate cancer cells. The middle image of the same section of lung tissue indicates activation of STAT3, a protein that is the downstream target of IL-6 signaling. The image at right of the same tissue section demonstrates the presence of PCNA in the invading prostate cells, a marker of metastasis.

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Courtesy of Trotman Lab/ CSHL

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