Biodistribution of Zr-89-labeled mAb: physiologic components. (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Biodistribution of Zr-89-labeled mAb: physiologic components.

Caption

(A) Reversible nonspecific uptake due to antibody in vascular tissue compartment and antibody entering tissue interstitium through paracellular pores, and through endothelial cells mediated by neonatal Fc-receptor, leaving tissue by convective transport through lymph flow. (B) Irreversible nonspecific uptake due to mAb degradation in lysosome, followed by residualization of Zr-89. (C) Specific uptake due to target engagement (target binding and internalization of mAb-target antigen).

Credit

Adapted from Lobo et al., J Pharm Sci. (2004;93), and Chen et al., AAPSJ (2012;14).

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