Liver Fat Gets a Wake-Up Call (IMAGE)

University of Pennsylvania School of Medicine

Liver Fat Gets a Wake-Up Call

Caption

This image shows a high-fat-diet (HFD)-induced fatty liver in wild-type mice, characterized by big lipid droplets in liver cells (top). Liver-specific HDAC3 knockout mice on HFD, note that the lipid droplets become smaller even though the total lipid content is increased (bottom).

Credit

Mitchell Lazar, M.D., Ph.D.; Zheng Sun, Ph.D., Perelman School of Medicine, University of Pennsylvania; <i>Nature Medicine</i>

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