Fig.1 (IMAGE)

Osaka University

Fig.1

Caption

Overview of this study. We performed 220 deep-phenotype genome-wide association studies (GWAS) in BioBank Japan, then performed trans-biobank meta-analyses with UK Biobank and FinnGen (ntotal = 628,000). As downstream analyses, we performed (i) cross-population comparisons of pleiotropy and genetic correlations, (ii) comprehensive HLA fine-mapping, and (iii) statistical decomposition of a matrix of summary statistics to gain insights into the underlying biology of current disease classifications by incorporating functional genomics, metabolomics, and biomarker data.

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© 2021 Saori Sakaue et al., Nature Genetics

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