TIN2 Blocks Fbx4 (IMAGE) Michigan Medicine - University of Michigan Caption The point at which Fbx4 and TIN2 bind to TRF1 overlaps. Where both are present, TIN2 binds to TRF1 first and blocks Fbx4 from binding. Credit University of Michigan Comprehensive Cancer Center Usage Restrictions For use in conjunction with stories about this research License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.