ATF6 Alpha: Master Regulator Pprotein (IMAGE) Stowers Institute for Medical Research Caption At the first hint of a cellular crisis triggered by the accumulation of misfolded and clumped proteins, ATF6 alpha springs into action and recruits a fleet of co-activators to assist in target gene activation. Credit Illustration: Mary O'Reilly, Ph.D., O'Reilly Science Art Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.