Mutated Cancer Cells (IMAGE)

Cold Spring Harbor Laboratory

Mutated Cancer Cells

Caption

The researchers exposed various mutated cancer cells to the cancer-killing drug OTS964. Nearly all strains (columns 1-3) were killed. Cancer cells flourished (stained violet) only when they mutated to resist the drug's ability to block their CDK11 protein receptors, indicating that CDK11 is essential for cancer growth, or a 'cancer addiction.'

Credit

Sheltzer lab/CSHL, 2019

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