Regulation Mechanism of Innate Immunity by SeP mRNA Induced by HCV Infection (IMAGE)

Kanazawa University

Regulation Mechanism of Innate Immunity by SeP mRNA Induced by HCV Infection

Caption

The liver infected by HCV augments selenoprotein P expression. Selenoprotein P gives rise to insulin resistance, accelerating pathogenesis of type-2 diabetes. On the other hand, mRNA of selenoprotein P binds to the regulatory domain (RD) of RIG-I, inhibiting production of type I interferon (IFN-β) that has antiviral activity. As a result, viral replication is augmented which causes resistance against antiviral treatments.

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Kanazawa University

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