Link Between BDNF and EGR3 May Explain the Pathophysiology of Bipolar Disorder (IMAGE)

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Link Between BDNF and EGR3 May Explain the Pathophysiology of Bipolar Disorder

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Lower BDNF levels observed in bipolar disorder patients may lead to reduced EGR3 levels. A dysfunctional pathway impairs several biological functions, including abnormal structural brain changes and cognitive and functional decline (known as neuroprogression). Disrupted neural circuits may explain the impaired neuroplasticity and resilience, increasing vulnerability to stress and mood episodes, all well-known characteristics of BD.

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Cezar Farias

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