Fig. 1 Overall Process (IMAGE)

Osaka University

Fig. 1 Overall Process

Caption

We collected fecal samples from 82 patients with rheumatoid arthritis (RA) and 42 healthy controls. We conducted a shotgun sequencing-based metagenome-wide association study, which consisted of three major bioinformatic analytic techniques for case-control comparisons: phylogenetic analysis, functional gene analysis, and pathway analysis. To assess the taxonomic relative abundance data, we conducted non-linear unsupervised clustering analysis and assessed correlations between clustering and the results of the case-control phylogenetic association tests. In addition, we compared pathway enrichment data for the metagenome with that generated by a host genome-wide association study in RA patients (East Asians, n = 22,515; Europeans, n = 58,284).

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Osaka University

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