Figure 2: The Mechanism for Production of High-Quality Pluripotent Epiblast Cells (IMAGE)

Osaka University

Figure 2: The Mechanism for Production of High-Quality Pluripotent Epiblast Cells

Caption

Activation of the TEAD transcription factor in the inner cell mass induces strong expression of pluripotency factors, which is required for epiblast formation. The expression of pluripotency factors (i.e., the quality of pluripotency) is highly variable among epiblast cells. Thus, the quality-control mechanism, which eliminates low-quality cells via apoptosis, operates to produce a high-quality epiblast.

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Osaka University

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