Fig. 1. (IMAGE)

Osaka University

Fig. 1.

Caption

Snake puzzle models of protein folding and amyloid fibril formation. Protein folding under Anfinsen's dogma leads to a unique functional native structure. Protein misfolding out of Anfinsen's dogma leads to amyloid structures. The two reactions are separated by the high free energy barrier of supersaturation. Once this barrier is broken by agitation or seeding, the equilibrium of folding and misfolding will be achieved.

Credit

Osaka University

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.