Mutations Affecting the Actin Regulator WDR1 Lead to Aberrant Lymphoid Immunity (IMAGE)
Caption
Confocal microscopy images showing morphological aberrations in leukocytes isolated from the peripheral blood of a patient carrying homozygous mutations in the gene encoding the actin regulator WDR1. The composite image shows a representative neutrophil with nuclear herniation, a monocyte assembling dense actin foci upon LPS stimulation, a T cell with accumulation of actin at the center of the anti-CD3 evoked synapse and a B cell emitting extended filopodia upon BCR/TLR stimulation. F-actin is shown in white and DAPI (for the neutrophil) in blue.
Credit
Loïc Dupré & Javier Rey-Barroso
Usage Restrictions
None
License
Licensed content