Mutations Affecting the Actin Regulator WDR1 Lead to Aberrant Lymphoid Immunity (IMAGE)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences

Mutations Affecting the Actin Regulator WDR1 Lead to Aberrant Lymphoid Immunity

Caption

Confocal microscopy images showing morphological aberrations in leukocytes isolated from the peripheral blood of a patient carrying homozygous mutations in the gene encoding the actin regulator WDR1. The composite image shows a representative neutrophil with nuclear herniation, a monocyte assembling dense actin foci upon LPS stimulation, a T cell with accumulation of actin at the center of the anti-CD3 evoked synapse and a B cell emitting extended filopodia upon BCR/TLR stimulation. F-actin is shown in white and DAPI (for the neutrophil) in blue.

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Loïc Dupré & Javier Rey-Barroso

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