Rewiring Cell Metabolism Slows Colorectal Cancer Growth: Interview with Jared Rutter, Ph.D. (AUDIO)
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A University of Utah-led study reports that cancers select against a protein complex called the mitochondrial pyruvate carrier, and re-introduction of MPC in colon cancer cells impairs several properties of cancer, including growth. The research, which appears online on Oct. 30 in Molecular Cell, implicates changes in a key step in metabolism -- the way cellular fuel is utilized -- as an important driver of colon cancer that is also likely to be important in many other cancer settings. Senior author Jared Rutter, Ph.D., professor of biochemistry at the University of Utah, describes the research findings, and their implications in developing new cancer therapies.
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