Dynein 1 (IMAGE) Colorado State University Caption The lissencephaly-1, or Lis1 protein, activates the dynein motor so it can transport cellular cargo. The dynein switches between "off" (left) and "on" (right). Lis1 binds to dynein when it is on, preventing the dynein from switching to an "off" state Credit Markus Lab/Colorado State University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.