Schematic Representation (IMAGE)

Kanazawa University

Schematic Representation

Caption

This is a schematic representation of the presumed dynamics and roles of alveolar macrophages (AMs) in lung metastasis. Interstitial macrophages (IMs) in lung metastatic foci can produce an inflammatory chemokine, CCL2, thereby recruiting blood-borne, CCR2-expressing AMs into lungs. The AMs abundantly produced LTB4, a potent inducer of tumor cell proliferation, and eventually promote the growth of tumor cells in the lung.

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Kanazawa University

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