Kinase Reaction of Lapatinib (IMAGE)

University of North Carolina Health Care

Kinase Reaction of Lapatinib

Caption

When the drug lapatinib inhibits the expression of the HER2 kinase in five different HER2-positive breast cancer cell lines, other kinases are also tamped down (blue) but several more kinases are activated (red), leading to drug resistance and tumor growth.

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Tim Stuhlmiller, PhD, UNC School of Medicine

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