Images of Mouse Hearts (IMAGE) Johns Hopkins Medicine Caption These are ultrasound images of mouse hearts. Absence of PDE-9 protects the heart from the deleterious effects of pressure overload as seen in the image in the upper right corner. By contrast, mice with intact PDF-9 genes developed enlarged, dilated hearts captured here by walls that are stretched far apart from each other, as shown in the lower left corner. Credit Johns Hopkins Medicine Usage Restrictions Must use only in connection with this press release. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.