哺乳动物胃肠道中吲哚的形成与转化 (IMAGE)

Science China Press

哺乳动物胃肠道中吲哚的形成与转化

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在胃肠道中，十字花科蔬菜释放的吲哚-3-甲醇（I3C）可转化成DIM和LTr1。I3C转化涉及3-亚甲基吲哚（3MI）的形成、甲醛释放、二氧化碳游离等步骤，甲醛在大肠中可与吲哚耦合生成I3C和DIM。I3C, indole-3-carbinol; I3A, indole-3-carbaldehyde; I3CA, indole-3-carboxylic acid; DIM, 3,3'-diindolylmethane; LTr1, 2-(indol-3-ylmethyl)-3,3'-diindolylmethane; 3MI, 3-methyleneindolium; IS-1 and IS-2, intermediate salts 1 and 2, respectively; WMR, Wagner-Meerwein rearrangement.

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