Nus-dependent transcription termination (IMAGE)

Penn State

Nus-dependent transcription termination

Caption

Model of NusA-dependent and NusG-dependent intrinsic termination of transcription of DNA into RNA. A new study shows that NusA and NusG together facilitate termination at about 88% of the intrinsic terminators in the bacteria Bacillus subtilis, helping to prevent unwanted transcription. (1) During transcription elongation, NusA and NusG bind RNA polymerase (blue). (2) NusA assists with RNA hairpin formation required for intrinsic termination and NusG helps to pause transcription allowing time for hairpin formation. (3) The RNA transcript is released.

Credit

Babitzke Laboratory and Dani Zemba, Penn State

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