New Role for Cancer Protein p53 (IMAGE)

University of Pennsylvania School of Medicine

New Role for Cancer Protein p53

Caption

The tumor suppressor p53 inhibits glucose-6-phosphate dehydrogenase (G6PD) by catalytically converting the active dimer to an inactive monomer. Through the inhibition of G6PD, p53 suppresses glucose consumption and biosynthesis. However, tumor-associated p53 mutants lose this function, which contributes to the Warburg effect and enhanced biosynthesis in tumor cells. The background shows images of p53 and G6PD localization in the cell.

Credit

Lili Guo, PhD, Peng Jiang, PhD, and Wenjing Du, PhD

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