Acute AMK effects on long-term object memory in young, middle-aged, and old mice. (IMAGE)

Tokyo Medical and Dental University

Acute AMK effects on long-term object memory in young, middle-aged, and old mice.

Caption

Three 1-minute training trials (A) revealed age-associated object memory decline in middle-aged and old mice at 1 day post-training (B). Systemic AMK (1 mg/kg) administered after a single 1-minute training trial enhanced object memory at 1 and 4 days post-training in all age groups (D-F). Data are presented as mean ± standard error. *P < .05 and **P < .01 indicate significantly different than chance performance (50%). Discrimination index (%) = time exploring novel object/ total object exploration time during test X 100

Credit

Department of Biology,TMDU

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