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Innovation Center of NanoMedicine

Caption

Short time-intervals (15 mins) between injection of biotin-PECAM1 antibody and injection of avidin-decorated nanomachines (avidin-NM) results in avidin-NM targeting to the lung (yellow), brain (blue), heart (red), and pancreas (purple) (a). However, targeting to peripheral organs decreases as a function of time-interval length, while targeting to the brain remains constant (b, c). Consequently, an 8h time-interval results in specific targeting of avidin-NM to the brain, with no targeting seen in peripheral organs (d). Avidin-NM accumulation was visualized in freshly excised brains (e) and fixed brain tissue (f).

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2020 Innovation Center of NanoMedicine

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