ENIGMA Bipolar Disorder Brain Map (IMAGE) University of Southern California Caption Bipolar patients tend to have gray matter reductions in frontal brain regions involved in self-control (orange colors), while sensory and visual regions are normal (gray colors). Credit Image courtesy of the ENIGMA Bipolar Consortium/Derrek Hibar et al. Usage Restrictions Please use caption and credit information as is. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.