Healthy Murine Spleen (IMAGE)

Harvard Medical School

Healthy Murine Spleen

Caption

In the murine spleen, lymphoid tissue (purple) is responsible for launching an immune response to blood-born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid tissue and contribute to immune system dysfunction.

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Photo courtesy of Dan Mordes, Eggan lab, Harvard Stem Cell Institute

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