AMYLOID 1 (IMAGE)

Rice University

AMYLOID 1

Caption

A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone sequence protected by the N-terminus tail in wild-type p53 but exposed by the mutation of a single amino acid. The strongest deviation happens in the domain at the green asterisk. The other three models show "open" conformations at the C-terminus caused by the mutation.

Credit

Kolomeisky Research Group/Rice University

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