TDP-43 Protein (IMAGE)

Cold Spring Harbor Laboratory

TDP-43 Protein

Caption

TDP-43 protein builds up in motor cortex and spinal cord of ALS patients, causing the nerves to die. The top three panels show nerve cells of ALS patients with extensive TDP-43 pathology in the motor cortex. Other ALS patients show little to no TDP-43 pathology, and look more like controls.

Credit

Gale Hammell lab/CSHL, 2019

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